Post by xg123 on Mar 5, 2012 14:29:22 GMT 7
The pharmaceutical calcium chloride is among the crucial species of pharmaceutical and chemical raw materials, primarily for the pharmaceutical business of calcium, also utilized as anti-allergic drugs and anti-inflammatory drugs, belongs to a high-end merchandise inside the calcium chloride. This item is of high demand inside the international market place, especially demand inside the Usa, Japan, Europe and also other regions at present. In China, with all the continuous improvement of people's residing standards, the demand for high-end calcium chloride products increases rapidly presently, it truly is priced at 16000-18000 / t, and gradually increased.
Because of the strict limitation in the top quality standards and production license (common) of drug and drug sales licensing restrictions, only few organizations develop pharmaceutical calcium chloride, but with the boost of marketplace demand, such high-end item is inside a shortage situation. For that reason, soqualified enterprises in China really should be develop and produce pharmaceutical calcium chloride to meet the wants of market place, which is constant with all the rules of market place economy, but in addition with all the fine and serialized direction of development of Chinese chemical goods.
Experimental Section
Industrial calcium carbonate and industrial hydrochloric utilized as raw materials of this experiment. The primary method circumstances like the following specifications: The pH of answer has to be four even though removal of arsenic; the time of activated carbon adsorption must be 1.5h; Control pH at eight.5 when get rid of iron, magnesium, aluminum, and so on. The pH has to be 4 ahead of resolution evaporates and temperature really should be 160 ?? in the time of evaporation.
Aspects that have an effect on item high quality
Arsenic is actually a damaging elements to human beings, industrial hydrochloric acid generally consists of arsenic. It really is easy to take away arsenic along with other insoluble impurities immediately after the complete reaction of calcium carbonate and hydrochloric acid, and filter at pH is 4.
Industrial hydrochloric acid is typically yellow, if it does not be decolored, the final item will show yellow. So, use activated carbon to adsorpt remedy which has been removed the arsenic. Via experiments, lastly decide that the adsorption temperature is 60¡æ and also the adsorption time is 1.5h.
The recation among iron, magnesium or aluminum and milk of lime reaction can create corresponding insoluble hydroxides. If pH is too low,the impurities won't remove competely to ensure that impacts the good quality of goods; on the contrary, if pH is too high, it will consume big amounts of milk lime and hydrochloric acid, boost the production fees. Right after a varity of experiments, resolution pH of eight.5 is appropriate when remove iron, magnesium and aluminum.
The solution which has removed iron is simple to absorb carbon dioxide inside the air consequently of creating carbonate which impact product quality, so the resolution beofore evaporation has to be adjusted to acidic. By experiments, pH ought to be controled as four.
Calcium chloride features a variety of crystalline hydrates: calcium chloride hexahydrate, calcium chloride dihydrate(10035-04-8), anhydrous calcium chloride. If the evaporating temperature is too low, it's most likely to form hexahydrate calcium chloride or four water calcium chloride, there could be a mixture of both; if the evaporation temperature is too high, it is going to lead to dihydrate calcium chloride shed water of crystallization and produce anhydrous calcium chloride dihydrate or possibly a mixture of both. By a number of experiments, the evaporation end point temperature could be controled at 160¡æ to generate calcium chloride dihydrate.
Conclusions
Using low cost industrial calcium carbonate and industrial hydrochloric acid as raw supplies, following basic chemical operations including dissolution, reaction, chemical impurity and evaporation, can manufacture high value-added and pharmaceutical grade chemical products that used broadly. calcium chloride dihydrate Though its method is mature and basic, businesses can nevertheless get high earnings and excellent efficiency just require low production fees. We can conclude that it is a worthwhile long-term improvement projects.
This write-up is reproduced from guidechem.com www.guidechem.com
Because of the strict limitation in the top quality standards and production license (common) of drug and drug sales licensing restrictions, only few organizations develop pharmaceutical calcium chloride, but with the boost of marketplace demand, such high-end item is inside a shortage situation. For that reason, soqualified enterprises in China really should be develop and produce pharmaceutical calcium chloride to meet the wants of market place, which is constant with all the rules of market place economy, but in addition with all the fine and serialized direction of development of Chinese chemical goods.
Experimental Section
Industrial calcium carbonate and industrial hydrochloric utilized as raw materials of this experiment. The primary method circumstances like the following specifications: The pH of answer has to be four even though removal of arsenic; the time of activated carbon adsorption must be 1.5h; Control pH at eight.5 when get rid of iron, magnesium, aluminum, and so on. The pH has to be 4 ahead of resolution evaporates and temperature really should be 160 ?? in the time of evaporation.
Aspects that have an effect on item high quality
Arsenic is actually a damaging elements to human beings, industrial hydrochloric acid generally consists of arsenic. It really is easy to take away arsenic along with other insoluble impurities immediately after the complete reaction of calcium carbonate and hydrochloric acid, and filter at pH is 4.
Industrial hydrochloric acid is typically yellow, if it does not be decolored, the final item will show yellow. So, use activated carbon to adsorpt remedy which has been removed the arsenic. Via experiments, lastly decide that the adsorption temperature is 60¡æ and also the adsorption time is 1.5h.
The recation among iron, magnesium or aluminum and milk of lime reaction can create corresponding insoluble hydroxides. If pH is too low,the impurities won't remove competely to ensure that impacts the good quality of goods; on the contrary, if pH is too high, it will consume big amounts of milk lime and hydrochloric acid, boost the production fees. Right after a varity of experiments, resolution pH of eight.5 is appropriate when remove iron, magnesium and aluminum.
The solution which has removed iron is simple to absorb carbon dioxide inside the air consequently of creating carbonate which impact product quality, so the resolution beofore evaporation has to be adjusted to acidic. By experiments, pH ought to be controled as four.
Calcium chloride features a variety of crystalline hydrates: calcium chloride hexahydrate, calcium chloride dihydrate(10035-04-8), anhydrous calcium chloride. If the evaporating temperature is too low, it's most likely to form hexahydrate calcium chloride or four water calcium chloride, there could be a mixture of both; if the evaporation temperature is too high, it is going to lead to dihydrate calcium chloride shed water of crystallization and produce anhydrous calcium chloride dihydrate or possibly a mixture of both. By a number of experiments, the evaporation end point temperature could be controled at 160¡æ to generate calcium chloride dihydrate.
Conclusions
Using low cost industrial calcium carbonate and industrial hydrochloric acid as raw supplies, following basic chemical operations including dissolution, reaction, chemical impurity and evaporation, can manufacture high value-added and pharmaceutical grade chemical products that used broadly. calcium chloride dihydrate Though its method is mature and basic, businesses can nevertheless get high earnings and excellent efficiency just require low production fees. We can conclude that it is a worthwhile long-term improvement projects.
This write-up is reproduced from guidechem.com www.guidechem.com